Biography:

Pregnant with her second child, Stephanie Arnold had detailed visions and foreboding from the 20 week ultrasound to delivering her child. She told everyone. The test were normal, but she was not. She kept seeing she would die during the delivery. And the day she went into give birth, she flatlined for 37 Seconds. The only reason she is alive is because one doctor, amidst the 10 consultations she had, truly listened and incorporated measures in the OR at the time of delivery and that is what saved her life.

Stephanie is now an award-winning, international best-selling author and inspirational speaker on a mission to help others realize that finding your voice and advocating for yourself can not only enhance our lives, but can very well save them.

Abstract:

Patients sometimes know something is wrong with their health, yet clinicians aren’t always paying attention to what is being communicated. According to a General Internal Medicine study in 2020, physicians give a patient 11 seconds to speak before being interrupted. Sometimes drawing the wrong diagnosis. If a patient is able to advocate for themselves, they won’t be excluded from their healthcare decision-making. Research shows an extra 19 seconds with an educated consumer will save lives.For the past 8 years I have worked with clinicians and patients to understand the disconnect between advocating for yourself and being truly heard by your clinicians. I have hundreds of emails from people reaching out about how they knew something, they felt they weren’t heard, tried to share the information or regretted not speaking up. I’m here to change the conversation.You will never regret speaking up and being wrong, but you will if you don’t and you are dead right.

Biography:

Abbas Majdi Seghinsara has completed his PhD at the age of 30 years from Tabriz University and start Anatomy and Embryology at Tabriz University of medical sciences.

Abstract:

Polycystic ovary syndrome (PCOS) is a disorder that supports endocrine abnormalities, characterized by an increase in GnRH and the ratio of LH to FSH. GnRH is the major molecule in reproduction that is affected by various intrinsic and external factors such as neurotransmitters and neuropeptides. PCOS is a highly inherited disease; Approximately 70- 60% of girls born from women with PCOS, exhibit PCOS phenotypes. Worldwide, 15-20% of women in reproductive age, have polycystic ovary syndrome. PCOS has severe and lifelong effects on women's health and wellness. Recently published international guidelines on PCOS state the need for clinical diagnosis of at least 2 of the 3 Rotterdam indicators: 1- Excessive levels of testosterone in the bloodstream or excessive body hair (hirsutism) 2- Absent or intermittent menstrual cycle 3- Polycystic ovaries on ultrasound Rotterdam indices create 4 PCOS phenotype models: Type A: HA + OD + PCOM Type B: HA + OD Type C: HA + PCOM Type D: OD + PCOM

The neurotransmitters inhibiting GnRH and LH, for example serotonin, dopamine, GABA and acetylcholine are all decreased, while glutamate, the main stimulus for GnRH and LH release, is increased in PCOS. The presence of an increased stimulus signal (glutamate) and a decrease in inhibitory flow (serotonin, dopamine, GABA, and acetylcholine) may indicate that the GnRH and LH are responsible and leading to an increase in the LH / FSH ratio observed in PCOS